775 Hyperactivation of sympathetic nerves drives melanocyte stem cell depletion
نویسندگان
چکیده
منابع مشابه
The biology of melanocyte and melanocyte stem cell.
The melanocyte stem cells of the hair follicle provide an attractive system for the study of the stem cells. Successful regeneration of a functional organ relies on the organized and timely orchestration of molecular events among distinct stem/progenitor cell populations. The stem cells are regulated by communication with their specialized microenvironment known as the niche. Despite remarkable...
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Hair graying is an obvious sign of human aging, yet little was known about its causes. Two recent papers provide compelling evidence that hair graying is due to incomplete melanocyte stem cell maintenance and identify Pax3 and Mitf as key molecules that help regulate the balance between melanocyte stem cell maintenance and differentiation.
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In post-ganglionic sympathetic neurons, biochemical and electron-microscopical evidence indicate that noradrenaline is stored within granules which, although smaller, resemble adrenal medullary chromaffin granules in some respects. This resemblance between neuronal and adrenal medullary granules has been extended by immunological and enzymic investigations which show that sympathetic nerve gran...
متن کاملChromogranins in sympathetic nerves
In post-ganglionic sympathetic neurons, biochemical and electron-microscopical evidence indicate that noradrenaline is stored within granules which, although smaller, resemble adrenal medullary chromaffin granules in some respects. This resemblance between neuronal and adrenal medullary granules has been extended by immunological and enzymic investigations which show that sympathetic nerve gran...
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Background: Uterine natural killer (uNK) cells are the most abundant leukocytes in pre-implantation endometrium and early pregnancy deciduas in humans and rodents. They are associated with structural changes in maternal spiral arteries but regulation of their re-cruitment and activation is incompletely understood. The major subpopulation of uNK cells in humans expresses CD56, the neural cell ad...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2020
ISSN: 0022-202X
DOI: 10.1016/j.jid.2020.03.789